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desvenlafaxine will increase the level or outcome of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Desvenlafaxine inhibits CYP2D6; with bigger desvenlafaxine doses (ie, 400 mg) minimize the CYP2D6 substrate dose by as many as 50%; no dosage adjustment essential with desvenlafaxine doses 7 consecutive days instantly pre